There are three easy options. Take Rte 22 East toward Altoona. Where 22 junctions with 220/99, you have two options, follow 220/99 northward toward Tyrone or stay with 22 East.
If you stay with 22 East, you will pass through Holidaysburg and start heading toward Huntingdon. About 10-15 miles East of Holidaysburg, you will reach a junction with Rte 453 (I believe, or is it 45?) at Waterstreet (there is a traffic light with 453/45 being the left-hand turn). If you stay with 22, a couple 100 yards along there is a left-hand turn toward Alexandria, make it. Travel a half mile or so until you come upon a warehouse/plant on the left and begin to look for another left just beyond the plant toward Barree. Follow this road another couple miles until you cross over the river. After crossing the river, you will make a left to head upstream. In another mile you will terminate at a parking area in Rothrock State Forest. You can fish from the bridge up to the parking area or upstream for a mile or more from the parking area.
Back to waterstreet, instead of going to Barree, turn left on 453/45. Up the hill a quarter mile maybe is a right-hand turn (I believe 45 splits to the right.) The sign should point to the village of Spruce Creek. Make the right and travel a couple miles along the mountain. At the bottom you will go under a train tressel. The river is directly in front of you. Access is open upstream for miles by making a left here. There is also a bit more river downstream from here as well, but if you make a right, you will shortly go over the river and away from it. The bridge is the upstream end of the Spring Ridge location.
Finally, back to 220/99. Instead of staying with 22, take 220/99 northward. Go past altoona 7-10 miles and exit at Tyrone. I believe this may be 453 as well. Turn right and head downstream. The river is on your right and may pass under and be on the left for a while. This road more or less parallels the stream and access is available all along here.
That should help. Good luck.
