So, from a trout fishing perspective:
- SE and SW PA suck. SW is worse as that corner of the state is virtually devoid of wild trout due to the slate/shale geologic base there. Gotta get at least as far east as the Laurel Highlands or North above 80. SE PA has good geology, and thus, some good streams. Just too many people and many of the streams are ruined.
- Anywhere north of 80 is pretty good. Most of it is ancient plateau cut by streams and heavily wooded. Small stream wild trout fishing, with bass and stocked fish in the bigger streams, and the occasional tailwater. Kind of a wilderness feel to it. The exception to this is the Ohio border, which is lower, flatter, more populated and less wooded. However, even there, you are a hop skip and a jump from Erie and it's excellent fisheries, and it's within day trip distance to some wild trout fisheries.
- The State College area kind of has it all. Limestoners. Freestoners. Limestoners with a freestone nature. Smallmouth bass waters in bigger waters. Plus, there's like actual civilization, so you're not out in the boonies.
- Southcentral PA has a number of very historic, classic, limestone streams. And a few freestoners as well. Lots of history and technical fishing, but not as good as farther north overall.
- The Pocono's is an excellent area. The freestoners there are probably better than anywhere else. Plus you have big river tailwater fisheries in the Lehigh and Delaware. The problem is access to much of it. Too much privatization. And private interests there DO post it, unlike much of the rest of the state, though the rest of the state is going in that direction as well. The Pocono's are just further along that path by a good deal.
Bellefonte would be my choice. Spring Creek right on your doorstep, and Big Fishing close enough. Day trippable to Penns or LJR. Also day trippable to the NC region, Lehigh, etc. Small town but only 10-15 minutes and an easy drive from the commercial center of State College, with all the amenities that brings in terms of shopping, restaurants, sports, etc.