Troutbuster, I started out with Neoprene, but quickly made the switch and never looked back. I do fish alot. I fish 12 months out of the year. I float stock 3 different streams and do a stream cleanup once a year. Do my breathables take a beating, yes. I used to buy cheaper pairs and end up getting a new pair about once a year. I finally decided to try a high end pair (Simms). Yes it cost me, but worth it. They are a durable, good product. I had the money so I spent it. Mine last about 3-4 yrs. before I sent them back to Simms for a repair. They patched up the pinholes and checked them out for a reasonable price.
As for washing them, I just hose them down from time to time. I hang them up and let them dry out.
Using them in the winter time, yes it can be cold out, but layer up inside. There are so many types of products for pants to wear underneath that using breathables in the winter is not that bad. I fish Erie steelhead in Dec., Jan. and Feb. with my breathables.
Using them in the summer, spring or fall is very nice. They are very light weight (since I like to travel and hike around alot) and you can roll them down. You can also buy a pair of waders that are designed to be converted from chest highs to waist highs. Sometimes if it is warm enough, I just wet-wade. I bought two pair of wet-wading pants and use them with just my wading boots.
If you have the cash, go for it, you won't be sorry.