Ryan's fly shop (Risenfly) moved locations. I believe he's in Big Beaver now.
Yes, the NW PA mountainous area has a lack of fly shops compared to the rest of the state. To the NW in Erie there's Foley's End and a lot of the other fishing stores have their share of fly gear. To the SW is RisenFly and Neshannock. To the SE and E is Brookville Fly & Bait, and Featherman Creations in Penfield.
But yes there's a huge hole around the ANF itself. From Oil City, Tionesta, Marienville, Kane, Warren, etc. I think you're close to an hour to the nearest fly shop, and that's good fishing country in there too.