The middle Yough is big and highly varying water. As DFG said 1000CFS is pretty good for wading. I think you can wade fish some spots up to 1200 maybe 1400, but options can be limited. There are some spots you can't wade at 500CFS. If you have a staff,I'd use it. It is not a river to be taken lightly.
Many years ago, warm evening and a smattering of rising fish... I'd worked out to point, that in failing light I couldn't seem to pick my way back from. finally slipping into shoulder deep cold water took my breath away. I tried my best to stay calm and bob and kick my way into shallower water. It was scary to say the least and had I panicked, well who knows?
Keep your expectations in check, it'll likely not be great, but it can be pretty darn good sometimes. If you invest some time to learn the river it can be fun. It does hold some exceptional fish to be sure. Then again sometimes you just walk away shaking your head.
Good luck.