>>So lets say I find a lake that from all research is known to be a good producer and I go there in Late October or anytime in November, on an overcast Day,>>
This would improve your odds, but early Spring is considerably better in my experience. Within a couple weeks of ice out.
>> would I fish for them exactly like I fish for Pickerel? 2-5 feet of water and around weedy areas or near rocks and cover?>
In late autumn, yes. In early spring though, the pike will be spawning and will often be in barely enough water to cover their backs. Often, this is sight fishing and can be pretty exciting...
>Do I need wire tippet or will 25lb mono do?>
It's a trade off. Wire leaders will help you land more fish, but some also tend to deaden fly action a bit. Good stiff 25-30 lb. mono will work but an occasional fish will shear you off.
>> Do you lift them from under the gills like I see online or is that harmful? Net only? I know that I mis-handle some fish.>>
Land them however you choose.. Under the gills is a pretty good way to avoid the thrashing machine that is a pike's mouth. Generally, try to avoid using a net. Pike, especially bigger pike tend to go pretty spastic when netted. I once saw a bigger (maybe 10 lb.) pike knock a partially full 2 gallon gas can clean out of a boat with his tail when netted. Try to exhaust the fish and bring him along side the boat and either cradle lift them or do the thing with the gills.
>>Buggers, Leaches, Baitfish patterns, frogs? What do you use?>>
Sometimes bigger flashy flies are better. Other times small dark flies are best. It's up to the pike and they change their minds often. Here are 10 good pike flies:
https://news.orvis.com/fly-fishing/tuesday-tip-top-10-flies-for-big-northern-pike
Flies with rabbit fur bodies/tails like #5 are very effective, but get waterlogged and difficult to cast. In contrast, you can cast flies like #1 and #2 all day without wearing yourself out.