Will second that wet wading is the way to go. However, I have been fishing a lot between Foul Rift and the Water Gap this summer. Have also heard good reports above the Gap from guys I trust. With the low, clear water this year the rocks in the rapids have a thicker than normal coating of algae that is super slick. Therefore, I have been forgoing the usual sneakers and have been using wading boots with tungsten cleats and neoprene wading socks. Even with the cleats some sections have been hard to wade.
The good news is that the fishing has been great. The better fish have been in the deeper runs/rapids during the day (where the wading on rocks is a bear). Shallower parts of rapids are full of the smaller guys. At night fishing the shallows at the tails of pools/mouths of creeks can be hot for fish busting schools of minnows, plus the wading is easier since the bottom in the shallows is usually sand or gravel.
I've been doing better so far with natural colored flies, but the white ones are picking up with the shadlings growing up. Always liked a pencil popper for night fishing shallows because I prefer surface action, but a white bugger or Zonker is just fine.
The canoer/tuber/rafter hatch has been unusually heavy this year, but I have also found them to be very polite and I haven't had any problems other than the non-stop "watchyacatchin?" Fished the Housatonic/Farmington two weeks ago and it was rare that the canoers had enough skills to keep away from the fishermen. The situation is better in the Delaware.
As far as the river being big, just worry about the water within casting range and the river will get smaller. Fishing the rapids is mostly like trout fishing. In the deeper runs few rocks come to the surface, but there are always foam lines and seams that concentrate fish.