For larger fish, in the fall its generally better in any trib thats adjacent to quality waters like the Little J . Problem is, you dont seem to get to enjoy your catch knowing you may have interupted its spawning cycle. Its great while your bringing them in but when you release them you dont feel too hot about yourself. I try to leave fish over redds alone and throw terrestrails. If you dont put something flashy in front of them to tick them off, spawning fish will usually leave it alone.
Its always worth my time to seek them out. Thats where some of my very best experiences come from. Heck, I did it this weekend and I dont even know the name of the little crick I was on.